Is yeast protein a complete protein?

Yeast protein can contain all nine indispensable amino acids; content is not the same as the amount the body can use.

Scientifically reviewed: September 25, 2026

Nine amino acids must come from food

Histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine are indispensable in adult diets. In one six-protein comparison, the tested yeast isolate contained 508 mg of indispensable amino acids per gram of protein and about 98.6 mg leucine per gram.

Composition→Digestion→Absorption→Utilization

These are four different things. That same study measured lower true and ileal digestibility for its yeast ingredient than for the comparison proteins. The careful conclusion is that yeast protein can provide a strong, complete profile while availability varies by preparation.

ANIMAL + IN VITRO

Evaluation of the nutritional quality of yeast protein in comparison to animal and plant proteins using growing rats and INFOGEST model

Yeast protein had a strong indispensable-amino-acid profile, but lower measured true protein and ileal amino-acid digestibility than comparison proteins in this experiment.

Model
Growing rats and a standardized laboratory digestion model
Sample
Preclinical experiment
Intervention
Yeast protein isolate · Study-specific
Comparator
Whey concentrate/isolate, soy, wheat and pea isolates

Cao X, Liu H, Yang M, Mao K, Wang X, Chen Z, Ran M, Hao L · 2025 · Food Chemistry

DOI 10.1016/j.foodchem.2024.141178 ↗
View references (1)
  1. Cao X, Liu H, Yang M, Mao K, Wang X, Chen Z, Ran M, Hao L. (2025). Evaluation of the nutritional quality of yeast protein in comparison to animal and plant proteins using growing rats and INFOGEST model. Food Chemistry. https://doi.org/10.1016/j.foodchem.2024.141178